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Prescribing InformationPatient Information Instructions for UseIndication Press Release
Read the phase 3 pivotal trial for
ZAVZPRETTM (zavegepant) published
March 2023 in The Lancet NeurologyRead the phase 3 pivotal trial for ZAVZPRETTM (zavegepant) published March 2023 in The Lancet Neurology

Article: Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial.

Authors: Richard B Lipton, MD, Robert Croop, MD, David A Stock, PhD, Jennifer Madonia, PA-C, Micaela Forshaw, MPH,
Meghan Lovegren, BS, et al.

Published: March 2023; Lancet Neurol 2023;22:209-17.

Learn about the phase 3 trial aimed to compare the efficacy, tolerability, safety, and timecourse of response for zavegepant nasal spray vs placebo in the acute treatment of migraine.

Article: Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial.

Authors: Richard B Lipton, MD, Robert Croop, MD, David A Stock, PhD, Jennifer Madonia, PA-C, Micaela Forshaw, MPH, Meghan Lovegren, BS, et al.

Published: March 2023; Lancet Neurol 2023;22:209-17.

Learn about the phase 3 trial aimed to compare the efficacy, tolerability, safety, and timecourse of response for zavegepant nasal spray vs placebo in the acute treatment of migraine.

Read The Lancet Neurology article here:
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INDICATION

ZAVZPRETTM (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine.

Important Safety Information Contraindications: Hypersensitivity to ZAVZPRET or any of its components.

Warnings and Precautions: Hypersensitivity reactions, including facial swelling and urticaria, have occurred with ZAVZPRET. If a hypersensitivity reaction occurs, discontinue ZAVZPRET and initiate appropriate therapy.

Adverse Reactions: Most common adverse reactions (occurring in ≥2% of patients treated with ZAVZPRET and greater than placebo) for ZAVZPRET vs placebo were taste disorders including dysgeusia and ageusia (18% vs 4%), nausea (4% vs 1%), nasal discomfort (3% vs 1%), and vomiting (2% vs 1%).

Drug Interactions: Avoid use with drugs that inhibit or induce OATP1B3 or NTCP transporters. Avoid use of intranasal decongestants; if unavoidable, administer intranasal decongestants at least 1 hour after ZAVZPRET administration.

Use in Specific Populations: Hepatic Impairment: Avoid use in patients with severe hepatic impairment. Renal impairment: Avoid use of ZAVZPRET in patients with creatinine clearance (CLcr) less than 30 mL/min.

Please click here for full Prescribing Information.IndicationZAVZPRET™️ (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine.

Please see Full Prescribing Information.