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Prescribing InformationPatient Information Instructions for UseIndication Press Release
MOAMOA

The ONLY CGRP receptor antagonist nasal spray1,2

The ONLY CGRP receptor antagonist nasal spray1,2

ZAVZPRET is rapidly absorbed in the nasal cavity, directly entering the bloodstream, avoiding GI absorption and first-pass metabolism.1,3

Peak plasma concentration of zavegepant was observed at approximately 30 minutes after a single 10 mg dose of the nasal spray.1

MOA=mechanism of action

MOA=mechanism of action

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Ben is a teacher with migraine who often endures the pain while teaching.

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References:Zavzpret. Package insert. Pfizer Inc.Lipton RB, Croop R, Stock DA, et al. Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial. Lancet Neurol. 2023;22(13):209-217. doi:10.1016/S1474-4422(22)00517-8Bitter C, Sutter-Zimmerman K, Surber C. Nasal drug delivery in humans. Curr Probl Dermatol. 2011;40:20-35. doi:10.1159/000321044Dubowchik GM, Conway CM, Xin AW. Blocking the CGRP pathway for acute and preventive treatment of migraine: the evolution of success. J Med Chem. 2020;63(13):6600-6623. doi:10.1021/acs.jmedchem.9b01810Favoni V, Giana L, Al-Hassany L et al. CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP? J Headache Pain. 2019;20(1):27.doi:10.1186.1186/s10194-019-0979-yDurham PL. CGRP-receptor antagonists — a fresh approach to migraine therapy? N Engl J Med. 2004;350(11):1073-1075. doi: 10.1056/NEJMp048016

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INDICATION

ZAVZPRETTM (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine.

Important Safety Information Contraindications: Hypersensitivity to ZAVZPRET or any of its components.

Warnings and Precautions: Hypersensitivity reactions, including facial swelling and urticaria, have occurred with ZAVZPRET. If a hypersensitivity reaction occurs, discontinue ZAVZPRET and initiate appropriate therapy.

Adverse Reactions: Most common adverse reactions (occurring in ≥2% of patients treated with ZAVZPRET and greater than placebo) for ZAVZPRET vs placebo were taste disorders including dysgeusia and ageusia (18% vs 4%), nausea (4% vs 1%), nasal discomfort (3% vs 1%), and vomiting (2% vs 1%).

Drug Interactions: Avoid use with drugs that inhibit or induce OATP1B3 or NTCP transporters. Avoid use of intranasal decongestants; if unavoidable, administer intranasal decongestants at least 1 hour after ZAVZPRET administration.

Use in Specific Populations: Hepatic Impairment: Avoid use in patients with severe hepatic impairment. Renal impairment: Avoid use of ZAVZPRET in patients with creatinine clearance (CLcr) less than 30 mL/min.

Please click here for full Prescribing Information.
IndicationZAVZPRET™️ (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine.

Please see Full Prescribing Information.