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Dosing

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Prescribing InformationPatient Information Instructions for UseIndication Press Release
DosingDosingDosingOne spray in one nostril with no need for priming Dosing information:1
  • Administration is one spray in one nostril with no need for priming
  • ZAVZPRET 10 mg nasal spray is supplied as a ready-to-use,single-dose disposable unit
  • Each carton contains 6 units, meant to treat 6 migraine attacks, as needed
  • Maximum cumulative dose that may be given in a 24-hour period is 10 mg. The safety of treating more than 8 migraines in a 30-day period has not been established
Additional prescribing considerations:1
  • Avoid concomitant administration of ZAVZPRET with drugs that inhibit or induce OATP1B3 or NTCP transporters
  • Avoid use in patients with severe hepatic impairment
  • Avoid use of ZAVZPRET in patients with creatinine clearance (CLcr) less than 30 mL/min
  • Can be co-administered with oral contraceptives and antidepressants
  • ZAVZPRET has a half-life of 6.55 hours
See ZAVZPRET in action:

Patient Instructions for Use Video

 Watch video Loading Download Instructions for Use Safety & Dosing Connect with a sales representative to learn more Request a representative References:Zavzpret. Package insert. Pfizer Inc.

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INDICATION

ZAVZPRETTM (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine.

Important Safety Information Contraindications: Hypersensitivity to ZAVZPRET or any of its components.

Warnings and Precautions: Hypersensitivity reactions, including facial swelling and urticaria, have occurred with ZAVZPRET. If a hypersensitivity reaction occurs, discontinue ZAVZPRET and initiate appropriate therapy.

Adverse Reactions: Most common adverse reactions (occurring in ≥2% of patients treated with ZAVZPRET and greater than placebo) for ZAVZPRET vs placebo were taste disorders including dysgeusia and ageusia (18% vs 4%), nausea (4% vs 1%), nasal discomfort (3% vs 1%), and vomiting (2% vs <1%).

Drug Interactions: Avoid use with drugs that inhibit or induce OATP1B3 or NTCP transporters. Avoid use of intranasal decongestants; if unavoidable, administer intranasal decongestants at least 1 hour after ZAVZPRET administration.

Use in Specific Populations: Pregnancy: It is not known if ZAVZPRET can harm an unborn baby. Lactation: It is not known whether ZAVZPRET passes into breast milk. Hepatic Impairment: Avoid use in patients with severe hepatic impairment. Renal impairment: Avoid use of ZAVZPRET in patients with creatinine clearance (CLcr) less than 30 mL/min.

Please click here for full Prescribing Information.IndicationZAVZPRET™ (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine.

Please see Full Prescribing Information.